Detalhe da pesquisa
1.
The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.
Cell
; 175(4): 1059-1073.e21, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30270039
2.
Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells.
Nature
; 621(7980): 840-848, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37674084
3.
A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation.
Immunity
; 50(4): 1043-1053.e5, 2019 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30902636
4.
Mycobacterial membrane protein Large 3-like-family proteins in bacteria, protozoa, fungi, plants, and animals: A bioinformatics and structural investigation.
Proteins
; 90(3): 776-790, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34739144
5.
Mycobacterium tuberculosis releases an antacid that remodels phagosomes.
Nat Chem Biol
; 15(9): 889-899, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31427817
6.
SQ109 inhibits proliferation of Leishmania donovani by disruption of intracellular Ca2+ homeostasis, collapsing the mitochondrial electrochemical potential (ΔΨm) and affecting acidocalcisomes.
Parasitol Res
; 119(2): 649-657, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31897791
7.
Aspergillus flavus squalene synthase as an antifungal target: Expression, activity, and inhibition.
Biochem Biophys Res Commun
; 512(3): 517-523, 2019 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30904161
8.
Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism.
Biochem Biophys Res Commun
; 511(4): 800-805, 2019 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30837154
9.
Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways.
J Am Chem Soc
; 140(24): 7568-7578, 2018 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29787268
10.
Structure-activity relationship investigation of coumarin-chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors.
Mol Divers
; 22(4): 893-906, 2018 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-29934672
11.
Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase.
Proc Natl Acad Sci U S A
; 112(35): 11048-53, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26283394
12.
Antiinfectives targeting enzymes and the proton motive force.
Proc Natl Acad Sci U S A
; 112(51): E7073-82, 2015 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26644565
13.
"Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase.
Angew Chem Int Ed Engl
; 57(3): 683-687, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29215779
14.
Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase.
Biochemistry
; 56(29): 3770-3779, 2017 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28660757
15.
Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors.
Chembiochem
; 18(10): 914-920, 2017 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28253432
16.
Head-to-Head Prenyl Synthases in Pathogenic Bacteria.
Chembiochem
; 18(11): 985-991, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28340291
17.
Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results.
Inorg Chem
; 56(13): 7558-7565, 2017 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28631925
18.
Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site.
Proc Natl Acad Sci U S A
; 111(25): E2530-9, 2014 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24927548
19.
Structure and Function of Four Classes of the 4Fe-4S Protein, IspH.
Biochemistry
; 55(29): 4119-29, 2016 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27357244
20.
Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.
Biochemistry
; 55(36): 5180-90, 2016 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27564465